CRP and Hyperglycemia: Chronic hyperglycemia can alter the metabolic phenotype of immune cells, impairing T cell function and leading to reduced immune surveillance.[31] Additionally, the hyperglycemic microenvironment can increase T-cell reactivity, causing inflammation and raising the risk of infection and infection-related mortality through receptor for advanced glycation end-products-mediated epigenetic modifications.[32] Third, the inflammation-driven effect of CRP.