However, post hoc analysis revealed that estradiol replacement in the context of hypertension significantly increased GPER mRNA expression in the aorta (pE2 = 0.08; p = 0.05; Figure 5a), cortex (pE2 = 0.002; p = 0.01; Figure 5b), and medulla (pE2 = 0.04; p = 0.04; Figure 5c). The gene discussed is GPER1; the disease is hypertensive disorder.