We also probed for Nox4 in the vasculature since our previous work shows that selective GPER activation reduces hypertension‐associated oxidative stress in the aorta and kidney and that genetic deletion of GPER removes female protection against ANG‐induced oxidative stress and vascular stiffening primarily through downregulation of Nox4 (Lindsey et al., 2011; Liu et al., 2016; Ogola et al., 2019). The gene discussed is GPER1; the disease is hypertensive disorder.