In head and neck squamous cell carcinoma (HNSCC), PRMT5-mediated H3R2me2s facilitates the recruitment of the MLL/SET1/WDR5 complex to the TWIST1 promoter, increasing H3K4me3 and TWIST1 transcription, thereby promoting EMT and lymph node metastasis [392]. This evidence concerns the gene KMT2A and head and neck squamous cell carcinoma.