CSC biology is regulated by interconnected networks, including pluripotency transcription factors (OCT4, SOX2, Nanog, KLF4, Myc), intracellular signaling pathways (Wnt, NF-κB, Notch), epigenetic mechanisms, the tumor microenvironment, and EMT processes [489, 490]. This evidence concerns the gene POU5F1 and neoplasm.