Concurrently, PRMT5-mediated methylation of ULK1 at R170 promotes T180 phosphorylation, activating autophagy via ATG13 and Beclin1 phosphorylation, which enhances mitochondrial clearance, reduces oxygen consumption, and supports tumor survival and proliferation (Fig. 6C) [341]. The gene discussed is PRMT5; the disease is neoplasm.