CTSD and Huntington disease: However, an intriguing observation was an elevation of the levels of LAMP1 in the STR in the HD brains, appearing as early as HD2 (Fig. 7A, B), which was otherwise not observed in the CTX (Fig. 7D, E), highlighting the levels of disease severity as depicted by the CTSD IHC found in HD STR compared with a lesser degree in the CTX, while the qPCR showed limited concordance, reiterating the findings of Johnson et al. comparing transcriptomic analysis with that of proteomics in AD (59).