IGHE and food allergy: Although IgE-mediated food allergy and EoE can co-exist (those with IgE-mediated food allergy can have a 9.1 fold higher risk of subsequent EoE) [27], the pathophysiology of EoE (see Statement #1) is that of delayed non-IgE-mediated food responses, providing a plausible mechanistic rationale for why skin prick and sIgE testing should be reserved for confirmation of potentially anaphylactic IgE-mediated food allergy and not EoE food triggers [130].