The inflammatory response is thought to be a result of stimulation of (non-IgE) immune cells in the esophagus by antigens releasing inflammatory cytokines that drive eosinophil recruitment [13]. In addition, the esophageal epithelium of an EoE patient has impaired barrier function that increases permeability to allergens which can trigger further disease [12, 14]. The gene discussed is IGHE; the disease is eosinophilic esophagitis.