As the core subunit of the NURF complex, Brodomain PHD finger Transcription Factor (BPTF) sustains non-neoplastic homeostasis by modulating chromatin accessibility (e.g., maintaining mammary epithelial differentiation and c-Myc-driven proliferation) [11–13], while propelling oncogenesis via cancer-specific mechanisms: cooperating with p50 NF-κB to promote COX-2-driven lung tumorigenesis [14]; epigenetically dysregulating the c-Myc/PLCG1/p-ERK axis to confer erlotinib resistance in gastric cancer [15]; and overexpressing to activate Cdc25A-mediated metastasis in colorectal cancer [16]. Here, MYC is linked to colorectal cancer.