The crucial pathophysiology of PD includes loss of dopaminergic neurons within the substantia nigra and aggregated α-synuclein (Lewy pathology), possibly due to genetic (e.g., SNCA, LRRK2, GBA) and environmental factors (e.g., pesticide exposure, prior head injury, beta-blocker use) [2]. The gene discussed is SNCA; the disease is Parkinson disease.