AGT and stroke disorder: The consensus was that the increased likelihood of cryptogenic or first-stroke in these FD patients was primarily due to disturbances in vasoreactivity and autoregulation in the vascular endothelium as a result of the accumulation of glycosphingolipids in those cells, suggesting vasospasm [18], reduced cerebral blood flow velocities and impaired autoregulation [19], and upregulation of angiotensin II [20] as key contributing mechanisms.