Irradiated tumor cell–derived exosomes display strong immunogenic activity, inducing IFN-related genes (IFN-β, Mx1, IFNAR1) in DCs and stimulating the release of IFN-β, IL-6, and CXCL10 [68], which together promote an inflammatory niche that supports T cell priming. The gene discussed is IFNB1; the disease is neoplasm.