A recent study on mammary adenocarcinoma showed that perivascular LYVE1+ TAMs secrete the platelet-derived growth factor-C (PDGF-C) homodimer, PDGF-CC, which signals to PDGF receptor-α (PDGFRA)-expressing stromal cells involved in blood vessel formation. This evidence concerns the gene CXCR1 and breast adenocarcinoma.