Given the established role of NT-proBNP as a practical surrogate for HF status in routine clinical practice, this subanalysis selected it as a key stratification variable to investigate whether baseline NT-proBNP levels (<125 pg/mL or ≥125 pg/mL) influence the comparative efficacy and safety of esaxerenone and trichlormethiazide. The gene discussed is NPPB; the disease is hydrops fetalis.