The proportion of patients with HF as a complication was higher in the high NT-proBNP subgroup (esaxerenone: 24.5% [12/49]; trichlormethiazide: 22.0% [9/41]) than in the low NT-proBNP subgroup (esaxerenone: 5.3% [10/188]; trichlormethiazide: 3.3% [7/212]). The gene discussed is NPPB; the disease is hydrops fetalis.