The high NT-proBNP subgroup had longer mean disease duration of hypertension and higher mean morning home, bedtime home, and office BP compared with the low NT-proBNP subgroup (esaxerenone and trichlormethiazide: duration of hypertension, 5.61 and 7.33 years vs 5.01 and 5.15 years; mean morning home BP, 150.5/87.7 and 146.4/86.8 mmHg vs 138.4/86.6 and 137.9/86.9 mmHg; mean bedtime home BP, 140.6/80.3 and 135.4/78.4 mmHg vs 133.8/81.7 and 134.5/82.5 mmHg; mean office BP, 155.1/82.8 and 145.7/80.5 mmHg vs 142.5/83.2 and 142.6/84.5 mmHg, respectively). The gene discussed is NPPB; the disease is hypertensive disorder.