The link between methylation of the AQP7 locus and expression levels of AQP7 in the adipose tissue aligns with prior research indicating that genetic and epigenetic variations in the AQP7 promoter region impact obesity and related metabolic disorders, including type 2 diabetes mellitus susceptibility in humans6–8. The gene discussed is AQP7; the disease is obesity due to melanocortin 4 receptor deficiency.