Due to interindividual variability in serum IL-6 levels according to the time of the same day and variations in the associated immune-metabolic comorbidities like obesity, we evaluated the IL-6/IL-10 ratio since serum IL-6 levels alone may not be an accurate indication of COVID-associated hyperinflammation28. Here, IL10 is linked to obesity due to melanocortin 4 receptor deficiency.