To this aim, MEFgCTRL and MEFgMecp2 were infected with HSV-1-KOS64 prior to assessment of the expression of Ifnβ at 6 hours and of antiviral IFN-stimulated genes such as Cxcl10, as 2’-5’-Oligoadenylate Synthetase-Like (Oasl1), 2’-5’-oligoadenylate synthetase 3 (Oas3) and Il6 at 16 hours post infection. This evidence concerns the gene OAS3 and infection.