We have shown that mTORC1 inhibition increases the protein expression of Nedd4-2, which is one of the E3 ubiquitin ligases that catalyzes ubiquitination of plasma membrane proteins and controls cell surface expression of SNAT2 and LAT1 transporters in PHT cells [28]. The gene discussed is NEDD4L; the disease is pulmonary hypertension, primary, 1.