Importantly, normalization of DEPTOR protein levels in FGR PHT cells restored Cdc42 expression (n = 6/group, p = 0.0001) to the level comparable of AGA PHT cells (Fig. 7a, b), suggesting that DEPTOR-mTOR signaling regulates the SNAT2 and LAT1 transporter trafficking in FGR PHT cell mediated by Cdc42 dependent F-actin membrane trafficking. The gene discussed is DEPTOR; the disease is pulmonary hypertension, primary, 1.