However, normalization of DEPTOR protein levels in FGR PHT cells restored Nedd4-2 protein expression (n = 6/group, p = 0.003) to the level comparable of AGA PHT cells (Fig. 6a, b), suggesting that DEPTOR-mTOR signaling regulates the membrane trafficking of the SNAT 2 and LAT1 in FGR PHT cell mediated by Nedd4-2 dependent ubiquitination. The gene discussed is MTOR; the disease is pulmonary hypertension, primary, 1.