Consistent with these reports, in the current study mTORC1 signaling activity was reduced, Nedd4-2 protein expression increased and ubiquitination of SNAT2 and LAT1 were higher in FGR PHT cells and restoration of mTORC1 signaling by DEPTOR normalization in FGR reversed all these changes. Here, DEPTOR is linked to pulmonary hypertension, primary, 1.