To study the molecular mechanisms linking elevated DEPTOR signaling to inhibition of System A and L amino acid transporter isoform intracellular trafficking in FGR PHT cells, we measured the System A (SNAT2) and System L (LAT1) transporter isoform ubiquitination in FGR PHT cell lysates following normalization of DEPTOR protein expression. The gene discussed is DEPTOR; the disease is pulmonary hypertension, primary, 1.