We recently demonstrated that inhibition of mTORC2 signaling decreases the protein levels of Cdc42 and Rac1, which are among the most well characterized members of the Rho family of GTPases that regulate F-actin assembly and disassembly and selectively suppresses LAT1/SNAT2 transporter trafficking to the plasma membrane in PHT cells [27]. This evidence concerns the gene RAC1 and pulmonary hypertension, primary, 1.