Using a subcutaneous transplantation tumor model with NAT10-knockdown PANC-1 cells and NAT10-overexpressing MIA PaCa-2 cells (Fig. 3A), we observed that NAT10 knockdown significantly reduced tumor growth and weight (Fig. 3B, S1A), whereas NAT10 overexpression markedly enhanced tumor growth (Fig. 3C, S1C). This evidence concerns the gene NAT10 and neoplasm.