Further single-cell ligand-receptor bubble plot analysis suggested that in pancreatic cancer epithelial cells, high expression of NAT10 and KRT8, compared with low expression, not only up - upregulated MIF, MDK, and LGALS9 but also strengthened the interaction with CD8 + T cells, thereby mediating immune evasion(Fig. S4F, G). This evidence concerns the gene MDK and familial pancreatic carcinoma.