To investigate the potential effect and the physiological relevance of MDMX, 14-3-3, and FOXO1 in tumorigenesis and progression of HCC, we assess the function and interaction of MDMX, 14-3-3, and FOXO1 in p53 null or p53 mutant HCC cell lines. Here, YWHAQ is linked to hepatocellular carcinoma.