Given that m6A-regulated lncRNAs affect TKI response and survival of leukemia patients, it will be interesting to see in the future whether these hitherto underappreciated roles for m6A-lncRNAs-PI3K cascade in anti-cancer resistance could serve as a foundation to design therapeutics that might overcome TKI resistance for this devastating cancer. The gene discussed is PIK3CG; the disease is cancer.