CRK and breast cancer: CypA promotes the colonization and proliferation of multiple myeloma cells via binding to CD147.[17] Furthermore, they identified CypA as an attractive target for the treatment of resistant multiple myeloma.[34] Charalampos G have reported that CypA binds to and enhances activation of CrkII, which stimulate breast cancer cell migration.[35] Our previous research has demonstrated elevated levels of CypA in ovarian cancer.