We demonstrate that CypA is overexpressed in chemotherapy‐resistant NSCLC and drives therapeutic evasion by competitively binding to the K37 site of SLC7A11, thereby blocking TRIM3‐mediated K11‐linked ubiquitination and proteasomal degradation of this critical ferroptosis regulator. The gene discussed is SLC7A11; the disease is non-small cell lung carcinoma.