The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers.[39] Studies revealed that SLC7A11 overexpression in cancer cells promotes GSH biosynthesis and ferroptosis resistance maintaining cell survival under oxidative stress conditions.[40] Of note, tumor tissue microarray and bioinformatics analysis indicated that CypA and SLC7A11 are vastly upregulated in patients with NSCLC. The gene discussed is PPIA; the disease is non-small cell lung carcinoma.