In patients with early DN (urine albumin-to-creatinine ratio [UACR] >30 mg/g and estimated glomerular filtration rate (eGFR) >90 ml/min/1.73 m2), Metformin treatment reduced body mass index (BMI) and homeostatic model assessment for insulin resistance (HOMA-IR) (Table 1). The gene discussed is ALB; the disease is liver dysplastic nodule.