Considering the established and emerging roles of PE in lipid droplet formation (41), very-low-density lipoprotein metabolism (42, 43, 44), and atherosclerosis (42), our findings demand rigorous future investigations to evaluate the response of mice lacking Oct1 and Oct2 with respect to hepatic function, plasma lipoprotein profile, and development of atherosclerosis, especially when fed a high-fat diet. The gene discussed is SLC22A1; the disease is atherosclerosis.