Given that TALIN-1, MRE11, and CCT8 interact with E-cadherin (30), that FASN, FLNA, and DDX3X are implicated in EMT (27, 32, 37, 38), and that FKBP4 expression is upregulated in colon cancers (39), we examined E-cadherin expression in human colorectal carcinoma HCT116 cells under the FKBP4 knockdown. The gene discussed is CCT8; the disease is malignant colon neoplasm.