TRPM8 and obesity due to melanocortin 4 receptor deficiency: While cold temperature and/or menthol (an edible cooling agent), seem to have diverse and confounding effects on obesity and/or thermogenesis, so far there is no direct evidence that specific pharmacological modulation of the Transient Receptor Potential cation channel subfamily Melastatin member 8 (TRPM8), a cold-temperature-activated ion channel, can indeed affect LD status within the mature adipocytes.