Meanwhile, strategies in NAD+ augmentation, such as via supplementing its precursors nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), inhibited pTau and improved cognitive function in a cross-species study involving a neuronal Tau (proaggregate F3ΔK280 Tau fragment) transgenic Caenorhabditis elegans model (21), triple-transgenic AD (3×Tg AD)/DNA polymerase β heterozygous knockout (Polβ+/−) mice (23), and 3×Tg AD mice (24). Here, POLB is linked to Alzheimer disease.