MAPT and tauopathy: To use this reporter gene system in worms with tauopathy-like disease, we crossed KH2566 worms with CK12, hTau[P301L] worms (47, 48), a well-characterized strain expressing pan-neuronal human Tau (hTau) 4R1N P301L that mimics tauopathy-like disease including impaired memory functions (21, 49).