While BAG1 appears to exacerbate AD pathology and promote neuronal death by stabilizing aggregation-prone Tau species that escape proteasomal degradation (128), we envisage that NR may regulate the BAG1/BAG3 balance in an EVA1C isoform–dependent manner in stabilizing of aggregation-prone Tau species; further experiments are necessary. This evidence concerns the gene BAG1 and Alzheimer disease.