Notably, when we treated normal diet (ND) mice with a GLP-1 receptor agonist (Exendin-4) during 6% DSS colitis, we observed an initial drop in weight, likely due to the known anorectic effect of GLP-1 receptor activation; however, only modest improvement was seen in parameters such as colon length and bacterial translocation. The gene discussed is GLP1R; the disease is colitis.