With the U-box domain attributed to the activity of E3 ubiquitin ligases, CHIP mediates the degradation of target proteins and contributes to the quality control of proteins and cell fate determination; thus, CHIP is a modulator of various physiological processes as well as diverse pathological conditions, including neurodegenerative diseases, cardiovascular diseases and tumors [31–34]. Here, STUB1 is linked to neurodegenerative disease.