The use of L-asparaginase of bacterial origin, has become a standard treatment in cases of childhood ALL; however, in the case of adults with this condition, the use of L-asparaginase has an increase in mortality caused by toxic effects and immunogenic reactions due to the bacterial origin (Escherichia coli or Erwinia chrysantemi) of this enzyme, as well as its glutaminase cross-activity [6,7]. This evidence concerns the gene GLS and acute lymphoblastic leukemia.