HLA-DQA1 and metabolic disease: Conversely, HLA-DQA1 was associated with increased risk for five diseases, most prominently Iron metabolism disorders (P = 1.50 × 10-8, OR = 1.60) and Disorders of mineral metabolism (P = 2.76 × 10-3, OR = 1.21) (S14 Table, Fig 7D).