Ferroptosis might play a key role in NAFLD‘s pathogenesis.Research on ferroptosis-related biomarkers mainly focuses on iron metabolism (Ferritin, Transferrin, Hepcidin), lipid peroxidation (ACSL4, GPX4, SLC7A11, etc.), lipoxygenases (such as ALOX15), lipid peroxidation products (MDA, 4-HNE), and antioxidant system markers (GSH, NRF2) [2]. The gene discussed is GPX4; the disease is metabolic dysfunction-associated steatotic liver disease.