LRIG1 and central nervous system cancer: LRIG1 protein level was found to be significantly lower in glioma compared to control tissue (0.096 ± 0.072 vs. 0.606 ± 0.303, p = 0.0004, Figure 1A), whereas LRIG1 gene transcription tended to be slightly higher (1.046 ± 0.769 vs. 0.808 ± 0.354, n.s., Figure 1F).