LRIG2 and central nervous system cancer: Whereas the opposite was seen on mRNA level, where LRIG2 gene transcription was significantly reduced in high-grade glioma (2.088 ± 1.173 vs. 1.243 ± 0.704, p = 0.0009, Figure 4J), with the greatest difference between grade II and III gliomas (2.088 ± 1.173 vs. 1.027 ± 0.510, p = 0.0011, Figure 4G), but also with a significance to sec.