At the metabolic enzyme level, both acetyl-CoA acetyltransferase 2 (ACAT2) and the aldo–keto reductase AKR1C3 have been shown to confer radioresistance to ESCC and esophageal adenocarcinoma (EAC) by inhibiting ferroptosis [130, 133]. Here, ACAT2 is linked to esophageal adenocarcinoma.