Likewise, upon epidermal infection with herpes simplex virus (HSV)1, which causes more localized infection than VV or LCMV, migratory cDC2s prime virus‐specific CD4+ T cells within 12 h of infection, while LN‐resident cDC1s prime CD8+ T cells 1–2 days post‐infection and co‐cluster with CD4+ T cells delivering help for CD8+ T cells [198]. Here, CD4 is linked to infection.