The transcriptomes (scRNA‐seq) of 2215 tumor cells from 18 HNC patients (Puram 2017) were analyzed, in which CHRNA5‐dominant cells were the most (47%), followed by the cells lacking expression of CHRNA3, CHRNA5, and CHRNA7 (41%) (Figure 5A). The gene discussed is CHRNA3; the disease is neoplasm.