Genetic alterations in TP53, RB1, STK11, KRAS, KEAP1, MYCL, SRY‐SOX2, PTEN, FGFR1, ASCL1, DLL3, NOTCH, ERBB2, EGFR, and SMARCA2 have also been reported in pulmonary LCNEC [35]. This evidence concerns the gene SOX2 and large cell neuroendocrine carcinoma.