Stx2, particularly its subtypes(e.g., Stx2a, Stx2c, and Stx2d), is strongly associated with the mostharmful consequence of STEC infections in humans, namely hemolyticuremic syndrome (HUS), while Stx1 typically is displayed by strainscausing diarrhea (sometimes bloody) due to intestinal cell damage,abdominal pain resulting from inflammation, fever, and dehydrationfrom fluid loss. Here, STX2 is linked to hemolytic-uremic syndrome.