Furthermore, we generated astrocyte‐specific Usp11 knockout (Usp11CKO) mice and found that astrocyte‐specific Usp11 knockout similarly demonstrated significant reductions in brain water content (Figure S2A, Supporting Information), alleviation of sensorimotor deficits (Figure S2B,C, Supporting Information), and mitigation of cognitive impairments (Figure S2D–G, Supporting Information) post‐ICH. Here, USP11 is linked to Cognitive impairment.