PGAM5 and autoimmune disease: Notably, mitochondria play crucial roles in regulating oxidative stress, inflammation, and cell death, and their dysfunction underlies the pathogenesis of diverse disorders including neurodegenerative, metabolic, cardiovascular, and autoimmune diseases.[24, 25] Therefore, we specifically analyzed mitochondrial gene expression changes among all DEGs post‐ICH, identifying PGAM5 as the most significantly altered mitochondrial gene compared to the control group (Figure 1B).