PGAM5 and diabetic kidney disease: Phosphoglycerate mutase family member 5 (PGAM5), a mitochondrial membrane‐bound phosphatase, is a critical regulator of mitochondrial dynamics and cell death.[20, 21, 22] For example, PGAM5 exacerbates podocyte injury and accelerates diabetic kidney disease progression by promoting mitochondrial fragmentation through dephosphorylation of dynamin‐related protein 1 (Drp1).[23] However, the precise involvement of PGAM5 in the reactivity of neurotoxic astrocytes and the progression of ICH remains undisclosed.