This is consistent with previous reports that astrocytes can recruit neutrophils and facilitate their infiltration via the CCL5‐CCR5 axis, thereby driving the pathogenesis of depression.[34] We also found that either a CCL5‐neutralizing antibody or a CCR5 antagonist attenuated microglial proinflammatory polarization (Figure 4M,N and Figure S4K,L, Supporting Information). Here, CCR5 is linked to major depressive disorder.