CGAS and Autoimmunity: mtDNA activates cGAS, a cytosolic sensor whose activation initiates STING‐dependent immunity, thus establishing the cGAS‐STING axis as a critical regulator in autoimmunity and inflammation.[37] mtDNA depletion attenuated cGAS‐STING pathway activation demonstrating that PGAM5 mediates proinflammatory effects through mtDNA‐dependent cGAS‐STING pathway (Figure 5F–G).