Reference on the promotion of PR‐positive cell proliferation by BPAF in vivo is relatively lacking, and only a reference on the promotion of ERα‐negative SKBR‐3 breast cancer cells proliferation by BPAF in vivo was found.[66] As for BPA, maternal BPA exposure promotes MCF‐7 cells injected into the flanks of ovariectomized mice to form tumors by 7 weeks post‐transplantation.[67] While our study provides compelling evidence for the oncogenic potential of BPAF through PR‐mediated pathways in vivo, it is important to acknowledge its limitation. Here, PGR is linked to breast cancer.