PGR and breast cancer: BPF and BPS induce protumorigenic changes in the morphology and proteome of human mammary gland organoids.[24] ERα activation‐DNMT‐TET2‐DNA hydroxymethylation participates in stimulated proliferation of breast cancer cells induced by BPA or BPS.[25] In addition to ER, PR is also a biomarker used routinely at diagnosis to characterize breast cancer, and participates in molecular subtyping and is a determining factor in treatment decisions.