In a mouse model of LC, MOF‐CpG‐DMXAA significantly enhanced the innate immune response by synergistically activating the cGAS‐STING‐NF‐κB signaling pathway, achieving an 80% tumor clearance rate and completely inhibiting tumor recurrence, providing a novel strategy for solid tumor immunotherapy.[351]. The gene discussed is STING1; the disease is neoplasm.