IL10 and neoplasm: In the TME of LC, M2 phenotype TAMs promote tumor progression, metastasis, and drug resistance by secreting immunosuppressive factors such as IL‐10 and TGF‐β, which facilitate angiogenesis and matrix remodeling.[239] The design of NMs targeting M2 phenotype TAMs has emerged as a crucial strategy for reshaping the immunosuppressive microenvironment.