In LC mouse models, local injection of oxygen microcapsules significantly enhanced RT efficacy, reduced TAM numbers, and reprogrammed pro‐tumor M2 phenotype TAMs into anti‐tumor M1 phenotype TAMs.[366] Clinically, Sor treatment activates the CXCR4/SDF‐1α axis, exacerbating hypoxia in LC and contributing to tumor progression, metastasis, immunosuppression, and ultimately, Sor resistance. This evidence concerns the gene CXCL12 and neoplasm.