NFKB1 and neoplasm: Therefore, attention has shifted to reprogramming tumor‐promoting M2 phenotype TAMs into tumoricidal M1 phenotype, a promising translational approach.[353] Several studies have used NMs to target TAM‐associated signaling pathways, such as STAT, NF‐κB, PI3Kγ/AKT, and ROS, to reprogram TAMs and reverse the immunosuppressive TME.