CD163 and neoplasm: CD163 is a cysteine‐rich class B scavenger receptor with a molecular weight of ≈130 kDa and belongs to the single‐pass transmembrane glycoprotein family.[242] As a key member of the scavenger receptor superfamily, CD163 is primarily expressed on the surface of monocytes and macrophages and is considered a highly specific marker of M2 phenotype TAM.[243]In addition to its role as an anti‐inflammatory immunomodulator, CD163 plays a critical role in tumor proliferation and metastasis as a member of the TAM family.