TBCE and neoplasm: KCs are well‐recognized for their intrinsic role in particle endocytosis via scavenger receptors.[186] Besides KCs, SECs are also involved in the clearance of negatively charged liposomes through scavenger receptor‐mediated stabilization.[187] Studies have shown that the shape of NMs significantly affects their circulation lifespan, flow characteristics, tumor accumulation, cellular uptake, and tumor tissue penetration.