Moreover, DEX‐CBX significantly increased the infiltration of natural killer T cells (5.7‐fold) and CD8+ T cells (3.9‐fold), while reducing M2 macrophages by 59%, leading to a tumor inhibition rate of 85.4%.[434] This study provides a novel approach to counteract LC immunosuppression caused by gut microbiota‐derived metabolites. This evidence concerns the gene CD8A and neoplasm.