CXCR4 has garnered significant attention over the past decade owing to its upregulation in various cancer types, including LC.[146] CXCR4‐associated signaling pathways, such as the CXCR4/stromal‐derived factor 1α (SDF1α) pathway, promote tumor growth and metastasis through multiple mechanisms. Here, CXCR4 is linked to neoplasm.