Our Composite Biomarker Cognitive Score combines neurodegenerative serum biomarkers, NfL, proinflammatory serum cytokine, IL-6, and TNFα, and HF biomarker NT-proBNP to predict an individual’s cognitive performance in HF individuals (Composite Biomarker Cognitive Score = NfL + NT-proBNP + IL-6 + TNFα). Here, IL6 is linked to hydrops fetalis.