It is possiblethat temperature variability may more strongly affect specific pathwaysof glucose metabolism, such as those related to insulin resistance(as reflected by fasting insulin, HOMA-IR,, and QUICKI,,) or long-term glucose regulation (HbA1c,), rather than short-term glucose concentrations (fasting glucoseand 2h glucose) or pancreatic β-cell function (HOMA-B). The gene discussed is INS; the disease is Insulin resistance.