Conversely, overexpression of CDK1 or CKS2 using the doxcycline-inducible retroviral transduction strategy used for MRTF-A re-expression failed to rescue proliferation of Mrtfab−/− MEFs, as did expression of myoferlin, an MRTF–SRF target gene that suppresses oncogene-induced senescence in liver cancer cells (Fig. S4E; see Hermanns et al., 2017). This evidence concerns the gene CDK1 and liver cancer.