In contrast, SRF inactivation induces apparent senescence in smooth muscle cells (Angstenberger et al., 2007; Werth et al., 2010) and activates oncogene-induced senescence in cancer cells lacking the DLC1 tumour suppressor, a RhoGAP (Hampl et al., 2013; Hermanns et al., 2017; Muehlich et al., 2012). This evidence concerns the gene ARHGAP1 and neoplasm.