While Rap2 can regulate integrin trafficking in T-cells and thyroid cancer cells (Stanley et al., 2012; Miertzschke et al., 2007; Dong et al., 2012), both FAs and acto-myosin stress fibers are also structures regulated by RhoA signaling (Hotulainen and Lappalainen, 2006; Julian and Olson, 2014; Chrzanowska-Wodnicka and Burridge, 1996; Ridley and Hall, 1992). Here, RHOA is linked to thyroid cancer.