Specifically, the Ras family of GTPases is known for regulating actin cytoskeleton dynamics and cell migration, largely through the Ras subfamily of GTPases (HRAS, KRAS, NRAS), which have been found to be mutated in individuals with cancer and drive cancer metastasis (Fuentes-Calvo et al., 2013; Collins et al., 2023; Bos et al., 2007; Prior et al., 2012). The gene discussed is KRAS; the disease is cancer.