More generally, both WHO-5 and ICC classifyB-ALL andT-ALL into multiple subgroups defined by cytogenetics (for example,B-ALL with t(9;22)(q34;q11)/BCR-ABL1,B-ALL with KMT2A rearrangement,T-ALL with TLX3 rearrangement, etc.),16 and they align on many criteria for diagnosis and risk stratification in acute leukemias. The gene discussed is TLX3; the disease is acute lymphoblastic leukemia.