HERV-W env transcripts significantly higher in schizophrenia patients (n=24) vs. controls (n=46) (p<0.01) by using quantitative reverse transcription polymerase chain reaction (qRT-PCR). Elevated TNF-α, IL-10 (p=0.01), reduced IFN-γ, IL-2 (p=0.05) in schizophrenia, but no correlation with HERV-W env. Here, IFNG is linked to schizophrenia.