Evidence suggests that ERVW-1 downregulates GANAB expression in SH-SY5Y neuroblastoma cells, activating the ATF6-mediated unfolded protein response, which upregulates CHOP and XBP1s, thereby inducing ER stress and impairing protein homeostasis in recent-onset schizophrenia (Xue et al., 2023). The gene discussed is ERVW-1; the disease is neuroblastoma.