With respect to autoimmune diseases, tolDC vaccines, which use modulators such as vitamin D3, rapamycin, or gene editing to overexpress IL‐10/PD‐L1, successfully induce antigen‐specific Treg cells, demonstrating the potential for stabilizing blood glucose levels and inhibiting autoimmunity in clinical trials for T1DM and RA. This evidence concerns the gene IL10 and Autoimmunity.