With respect to autoimmune diseases, tolDC vaccines, which use modulators such as vitamin D3, rapamycin, or gene editing to overexpress IL‐10/PD‐L1, successfully induce antigen‐specific Treg cells, demonstrating the potential for stabilizing blood glucose levels and inhibiting autoimmunity in clinical trials for T1DM and RA. Here, CD274 is linked to autoimmune disease.