In multivariable Fine and Gray regression analyses, NfL serum levels (sHR 1.01, 95% CI 1.00–1.01, p < 0.001) remained independently associated with the development of post‐TIPS HE, while GFAP was not (p = 0.3) (Table S8 and S9). This evidence concerns the gene NEFL and hereditary elliptocytosis.