Our investigations reveal that aging differentially modulates restraint stress-induced ER stress responses: while suppressing the upregulation of protective ER stress-related genes (Fmo2, Creb3l1, Tmtc3, Bak1), it promotes the induction of Pgap1 change associated with cognitive decline (Yuan et al., 2023). This evidence concerns the gene CREB3L1 and Mental deterioration.