To address this unmet need, the present study was designed with two major objectives: (i) to comprehensively evaluate the anti‐proliferative and tumor‐suppressive effects of different fractions of F. pandurata, with a specific focus on its petroleum ether fraction (FPHPE), in both in vitro and in vivo HCC models; and (ii) to elucidate the mechanistic basis of its activity, focusing on mitochondrial apoptosis induction and inhibition of the JAK2/STAT3 inflammatory axis. Here, STAT3 is linked to hepatocellular carcinoma.