Moreover, KEGG pathway enrichment analysis revealed that the DEGs were significantly associated with key oncogenic signaling pathways, including the PI3K-Akt, Rap1, and transforming growth factor β (TGF-β) pathways, as well as with cell adhesion (Figure 6B), all of which are known to be critical in tumor initiation and metastasis (Supplementary Table S3). This evidence concerns the gene PIK3CA and neoplasm.