To validate the bioinformatic findings, we established a mouse AP model by the combination of caerulein and LPS, as confirmed by serum amylase, lipase, and trypsin activity, and MPO activity in pancreatic tissue (Figures 9A-D), as well as H&E histopathological assessment (Figures 9F, G). The gene discussed is MPO; the disease is alkaline phosphatase measurement.